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‣Technology
More than a hundred billion cells are eliminated each day from a normal healthy body.
The nucleic acids (DNA and RNA) from each of these cells is broken into smaller pieces which are then disposed of in a variety of ways. Most of these DNA fragments are carried away by the blood stream that perfuses every tissue and organ of the body. Scientists at TrovaGene were the first to discover that, contrary to expectations, a large portion of those fragments actually passes through the kidneys and appears in the urine. It is now established that urine contains genetic DNA markers representing cells, tissues, and organs from throughout the entire body. Of special interest to medical diagnostics is the fact that many DNA fragments detectable in urine come from viruses, bacteria, and other infectious organisms in the body. Similarly, tumor-specific genetic markers may be detected in urine as would markers from genetically distinct transplanted cells, tissues or organs. During pregnancy the developing fetus produces similar DNA fragments that pass into the mother’s blood stream and may be found in urine specimens as early as the seventh week.
This means more sensitive and earlier detection of many diseases may be possible. Tumors and metastatic cancer may be detectable much more effectively and earlier than before. This may mean that genetically distinct stem cells and transplanted organs may be monitored more frequently and more safely than currently possible using blood or biopsy tests. This also means that a broad array of molecular diagnostics may be performed on a single laboratory platform that is safer and more efficient than those currently used.
TrovaGene´s patented proprietary technology utilizes this fragmented DNA material which has crossed the kidney barrier (hereafter referred to as transrenal DNA or TR-DNA) and is available in urine to provide vital diagnostic information about health conditions.
TROV.PK
